The Globe was a prominent newspaper during the Andrew Jackson administration, serving as the primary organ for the Democratic Party and the administration's policies. Francis Preston Blair, the editor noted in the masthead, was a close advisor to President Jackson and a key figure in the "Kitchen Cabinet".

This edition is notable for it's advertisements of Frankenstein; or, The Modern Prometheus the seminal 1818 Gothic novel[a] written by English author Mary Shelley. Frankenstein tells the story of Victor Frankenstein, a young scientist who creates a sapient creature from different body parts in an unorthodox scientific experiment. Shelley started writing the story when she was 18 and staying in Bath,[2] and the first edition was published anonymously in London on 1 January 1818, when she was 20. Her name first appeared in the second edition, which was published in Paris in 1821.

The newspaper has many interesting articles including a remarkable incident of a whaling captain dragged by his harpoon rope down the depths of the Atlantic by a raging whale (sounds like a familiar novel!). And, an early hoax regarding a found mermaid!